5-Substituted 1,2,4-Triazole-3-Carboxylates and 5-Substituted Ribavirin Analogs Synthesis
| Autor: | Alexander N. Prutkov, Lyubov E. Grebenkina, Mikhail V. Chudinov, Andrey V. Matveev |
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| Rok vydání: | 2021 |
| Předmět: |
General Immunology and Microbiology
Nucleoside analogue General Neuroscience Ribavirin Carboxylic Acids 1 2 4-Triazole Health Informatics Biological activity Nucleosides Triazoles Combinatorial chemistry General Biochemistry Genetics and Molecular Biology Nucleobase Medical Laboratory Technology chemistry.chemical_compound chemistry medicine General Pharmacology Toxicology and Pharmaceutics medicine.drug |
| Zdroj: | Current protocolsLiterature Cited. 1(11) |
| ISSN: | 2691-1299 |
| Popis: | Ribavirin analogs substituted at position 5 of the heterocyclic base are interesting for their biological activity. This protocol describes a synthetic route to several such ribavirin analogs with a wide range of substituents.© 2021 Wiley Periodicals LLC. Basic Protocol 1: Synthesis and purification of 5-substituted ethyl 1,2,4-triazole-3-carboxylates - synthetic precursors of nucleobases Basic Protocol 2: Synthesis and purification of protected 1,2,4-triazole nucleoside analogs Basic Protocol 3: Synthesis and purification of 5-substituted ribavirin analogs. |
| Databáze: | OpenAIRE |
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