Bacterial eradication by clinafloxacin, CI-990, and ciprofloxacin employing MBC test, in-vitro time-kill and in-vivo time-kill studies
| Autor: | Jeffrey W. Gage, Steven L. Yoder, Michael D. Huband, Michael A. Cohen, Gregory E. Roland |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Microbiology (medical)
Micrococcaceae Gram-positive bacteria Microbial Sensitivity Tests Quinolones Gram-Positive Bacteria medicine.disease_cause Microbiology Mice chemistry.chemical_compound Anti-Infective Agents Ciprofloxacin In vivo Gram-Negative Bacteria medicine Animals Pharmacology (medical) Naphthyridines Antibacterial agent Pharmacology Dose-Response Relationship Drug biology Bacterial Infections biology.organism_classification Antimicrobial Disease Models Animal Infectious Diseases chemistry Staphylococcus aureus Female Clinafloxacin Fluoroquinolones medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 41:605-614 |
| ISSN: | 1460-2091 |
| DOI: | 10.1093/jac/41.6.605 |
| Popis: | Bactericidal activities of clinafloxacin, CI-990 and ciprofloxacin were examined and compared for a small collection of gram-positive and gram-negative pathogens. In-vitro antimicrobial activities were measured by MIC, MBC and time-kill studies; in-vivo efficacy of each drug was assessed in an acute lethal mouse infection model that monitored median protective dose, eradicative dose and time-kill in blood. In general, for all test methods, activity of clinafloxacin exceeded that of CI-990, which in turn exceeded that of ciprofloxacin. Improvement in clinafloxacin and CI-990 activity over ciprofloxacin was more apparent against gram-positive cocci; differences were less noticeable against Escherichia coli and Pseudomonas aeruginosa. Clinafloxacin activity was notably high against Staphylococcus aureus and, against ciprofloxacin-resistant strains, this high activity was maintained in vitro and measurable activity was demonstrated in vivo. |
| Databáze: | OpenAIRE |
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