Assessment of alpha- and beta-adrenoceptor blocking actions of labetalol
| Autor: | D. A. Richards, J Tuckman, BN Prichard |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adult
Male medicine.medical_specialty Adrenergic beta-Antagonists Alpha (ethology) Blood Pressure Pharmacology Phenylephrine Heart Rate Isoprenaline Internal medicine Heart rate medicine Humans Pharmacology (medical) Labetalol cardiovascular diseases Adrenergic alpha-Antagonists Dose-Response Relationship Drug Chemistry musculoskeletal neural and ocular physiology Isoproterenol Endocrinology Blood pressure Ethanolamines Antagonism medicine.drug circulatory and respiratory physiology Research Article |
| Zdroj: | British journal of clinical pharmacology. 3(5) |
| ISSN: | 0306-5251 |
| Popis: | Isoprenaline dose-response curves plotting increases in heart rate before and after labetalol are suggestive of competitive antagonism at beta-adrenoceptor sites. Phenylephrine dose-response curves using increases in systolic pressure before and after labetalol are suggestive of competitive antagonism at alpha-adrenoceptor sites. The ratio of alpha:beta-adrenoceptor antagonism induced by labetalol is approximately 1:3. Peak pharmacological responses after a single oral dose of labetalol (400 mg) occurred between 90-120 min after administration. |
| Databáze: | OpenAIRE |
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