Diminished susceptibility to daptomycin accompanied by clinical failure in a patient with methicillin-resistant Staphylococcus aureus bacteremia
| Autor: | Christine C. Ginocchio, BS Maureen Bythrow, Susan Condon, David Hirschwerk |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Staphylococcus aureus Micrococcaceae Epidemiology medicine.drug_class 030106 microbiology Antibiotics Microbial Sensitivity Tests medicine.disease_cause Microbiology 03 medical and health sciences Minimum inhibitory concentration 0302 clinical medicine Fatal Outcome Daptomycin Drug Resistance Bacterial medicine Humans 030212 general & internal medicine Antibacterial agent Aged 80 and over biology business.industry biochemical phenomena metabolism and nutrition Staphylococcal Infections bacterial infections and mycoses biology.organism_classification medicine.disease Methicillin-resistant Staphylococcus aureus DNA Fingerprinting Infectious Diseases Bacteremia Female Methicillin Resistance business medicine.drug |
| Zdroj: | Infection control and hospital epidemiology. 27(3) |
| ISSN: | 0899-823X |
| Popis: | We cared for a patient with methicillin-resistant Staphylococcus aureus bacteremia who experienced clinical failure with daptomycin. The failure was accompanied by progressive elevation of the daptomycin minimum inhibitory concentration during treatment. DNA fingerprinting confirmed that the minimum inhibitory concentration elevation occurred within the same strain of methicillin-resistant Staphylococcus aureus. This observation provides important new information to clinicians who adopt this promising drug for treatment of serious infections caused by methicillin-resistant Staphylococcus aureus. |
| Databáze: | OpenAIRE |
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