Resveratrol: Why Is It a Promising Therapy for Chronic Kidney Disease Patients?
Autor: | Juliana F. Saldanha, Peter Stenvinkel, Viviane O. Leal, José Carlos Carraro-Eduardo, Denise Mafra |
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Rok vydání: | 2013 |
Předmět: |
Aging
medicine.medical_specialty Inflammation Mechanistic Target of Rapamycin Complex 2 Review Article mTORC1 Mechanistic Target of Rapamycin Complex 1 Resveratrol Pharmacology medicine.disease_cause Biochemistry chemistry.chemical_compound Internal medicine Stilbenes medicine Humans lcsh:QH573-671 Renal Insufficiency Chronic Transcription factor PI3K/AKT/mTOR pathway biology lcsh:Cytology TOR Serine-Threonine Kinases food and beverages Cell Biology General Medicine medicine.disease Oxidative Stress Endocrinology chemistry Multiprotein Complexes Sirtuin biology.protein medicine.symptom Oxidative stress Kidney disease |
Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2013 (2013) |
ISSN: | 1942-0994 1942-0900 |
DOI: | 10.1155/2013/963217 |
Popis: | Resveratrol, a phenolic compound found in various plants, including grapes, berries, and peanuts, shows promise for the treatment of cancer, aging, type 2 diabetes, and cardiovascular diseases. Resveratrol can promotetranscription factor nuclear factor-erythroid 2-related factor 2(Nrf2) activation, increase the expression level of SIRT-1, which is a sirtuin family protein, and reduce mTOR pathway signaling. This compound has anti-inflammatory properties in that it inhibits or antagonizes the nuclear factor-κB (NF-κB) activity, which is a redox-sensitive transcription factor that coordinates the inflammatory response. Inflammation and oxidative stress, which are common features in patients with chronic kidney disease (CKD), are interrelated and associated with cardiovascular disease and the progression of CKD itself. Because of the modulation of the mechanisms involved in the inflammatory-oxidative stress cycle, resveratrol could play an important role in controlling CKD-related metabolic derangements. Although resveratrol supplementation in theory is a promising therapy in this patient group, there are no studies evaluating its effects. Thus, the present review aims to describe the role of resveratrol in inflammation and oxidative stress modulation and its possible benefits to patients with CKD. |
Databáze: | OpenAIRE |
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