Persistent Maintenance of Intermediate Memory B Cells Following SARS-CoV-2 Infection and Vaccination Recall Response

Autor:	Jernej Pušnik, Julia König, Karola Mai, Enrico Richter, Jasmin Zorn, Hannah Proksch, Bianca Schulte, Galit Alter, Hendrik Streeck
Rok vydání:	2022
Předmět:	CD4-Positive T-Lymphocytes COVID-19 Vaccines Time Factors SARS-CoV-2 Vaccination Immunology COVID-19 Antibodies Viral Antibodies Neutralizing Microbiology Interferon-gamma Memory B Cells Virology Insect Science Spike Glycoprotein Coronavirus Humans Immunologic Memory
Zdroj:	Journal of Virology. 96
ISSN:	1098-5514 0022-538X
DOI:	10.1128/jvi.00760-22
Popis:	Robust population-wide immunity will help to curb the SARS-CoV-2 pandemics. To maintain the immunity at protective levels, the quality and persistence of the immune response elicited by infection or vaccination must be determined. We analyzed the dynamics of B cell response during 12 months following SARS-CoV-2 infection on an individual level. In contrast to antibodies, memory B cells specific for the spike (S) protein persisted at high levels throughout the period. These cells efficiently secreted neutralizing antibodies and correlated with IFN-γ-secreting CD4
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158ab25cae27641ac8a05cac68d54cf7 https://doi.org/10.1128/jvi.00760-22 Zobrazit plný text záznamu