Mechanical testing of glutaraldehyde cross-linked mitral valves. Part two: Elastic and viscoelastic properties of chordae tendineae
| Autor: | Kheng Lim Goh, Daniel M. Espino, Bernard M. Lawless, Vera Gramigna, Rhiannon Northeast, Matthew Constable, Hanna E. Burton, Keith Buchan |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Swine 0206 medical engineering Uniaxial tension 02 engineering and technology Viscoelasticity chemistry.chemical_compound stomatognathic system Mitral valve medicine Animals Mechanical Engineering General Medicine Dynamic mechanical analysis 021001 nanoscience & nanotechnology 020601 biomedical engineering Biomechanical Phenomena medicine.anatomical_structure chemistry Glutaral Mechanical Tests Chordae Tendineae Mitral Valve sense organs Glutaraldehyde Chordae tendineae 0210 nano-technology psychological phenomena and processes Biomedical engineering |
| Zdroj: | Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 235:291-299 |
| ISSN: | 2041-3033 0954-4119 |
| DOI: | 10.1177/0954411920975938 |
| Popis: | The aim of this study was to assess whether the mechanical properties of mitral valve chordae tendineae are sensitive to being cross-linked under load. A total 64 chordae were extracted from eight porcine hearts. Two chordae (posterior basal) from each heart were subjected to uniaxial ramp testing and six chordae (two strut, two anterior basal and two posterior basal) were subjected to dynamic mechanical analysis over frequencies between 0.5 and 10 Hz. Chordae were either cross-linked in tension or cross-linked in the absence of loading. Chordae cross-linked under load transitioned from high to low extension at a lower strain than cross-linked unloaded chordae (0.07 cf. 0.22), with greater pre-transitional (30.8 MPa cf. 5.78 MPa) and post-transitional (139 MPa cf. 74.1 MPa) moduli. The mean storage modulus of anterior strut chordae ranged from 48 to 54 MPa for cross-linked unloaded chordae, as compared to 53–61 MPa cross-linked loaded chordae. The mean loss modulus of anterior strut chordae ranged from 2.3 to 2.9 MPa for cross-linked unloaded chordae, as compared to 3.8–4.8 MPa cross-linked loaded chordae. The elastic and viscoelastic properties of chordae following glutaraldehyde cross-linking are dependent on the inclusion/exclusion of loading during the cross-linking process; with loading increasing the magnitude of the material properties measured. |
| Databáze: | OpenAIRE |
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