Effects of Surface-Deacetylated Chitin Nanofibers in an Experimental Model of Hypercholesterolemia
| Autor: | Takeshi Tsuka, Norihiko Ito, Tomohiro Osaki, Yusuke Murahata, Hironori Izawa, Tomone Nagae, Kazuo Azuma, Shinsuke Ifuku, Takeshi Nagai, Tomohiro Imagawa, Yoshiharu Okamoto, Minoru Morimoto, Hiroyuki Saimoto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
chitin nanofibers Nanofibers Phospholipid Administration Oral Chitin Lipoproteins VLDL Article Catalysis Inorganic Chemistry lcsh:Chemistry chemistry.chemical_compound surface-deacetylated chitin nanofibers Oral administration Internal medicine medicine Animals Humans Physical and Theoretical Chemistry Cellulose Molecular Biology lcsh:QH301-705.5 Phospholipids Spectroscopy biology hypercholesterolemia Cholesterol Anticholesteremic Agents Organic Chemistry Cholic acid General Medicine Computer Science Applications rats Endocrinology chemistry Alanine transaminase Blood chemistry Biochemistry lcsh:Biology (General) lcsh:QD1-999 biology.protein chitosan Lipoprotein Chylomicron |
| Zdroj: | International Journal of Molecular Sciences, Vol 16, Iss 8, Pp 17445-17455 (2015) International Journal of Molecular Sciences Volume 16 Issue 8 Pages 17445-17455 |
| ISSN: | 1422-0067 |
| Popis: | This study evaluated the effects of oral administration of surface-deacetylated chitin nanofibers (SDACNFs) on hypercholesterolemia using an experimental model. All rats were fed a high cholesterol diet with 1% w/w cholesterol and 0.5% w/w cholic acid for 28 days. Rats were divided equally into four groups: the control group was administered 0.05% acetic acid dissolved in tap water, and the SDACNF, chitosan (CS), and cellulose nanofiber (CLNF) groups were administered 0.1% CNF, CS, or CLNF dissolved in the tap water, respectively, during the experimental period. Changes in body weight, intake of food and water, and organ weight were measured. Serum blood chemistry and histopathological examination of the liver were performed. Administration of SDACNF did not affect body weight change, food and water intake, or organ weights. Administration of SDACNF and CS decreased the diet-induced increase in serum total cholesterol, chylomicron, very-low-density lipoprotein, and phospholipid levels on day 14. Moreover, oral administration of SDACNFs suppressed the increase of alanine transaminase levels on day 29 and suppressed vacuolar degeneration and accumulation of lipid droplets in liver tissue. These data indicate that SDACNF has potential as a functional food for patients with hypercholesterolemia. |
| Databáze: | OpenAIRE |
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