Prooxidant-antioxidant balance in patients with phenylketonuria and its correlation to biochemical and hematological parameters
| Autor: | Sabrieh Amini, Mohammad Saeed Hakhamaneshi, Asadollah Fathollahpour, Mohammd Saleh Hajir, Pedram Andalibi, Somayeh Tavana, Mohammad Abdi, Azin Ardalan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Antioxidant Endocrinology Diabetes and Metabolism medicine.medical_treatment Phenylalanine Oxidative phosphorylation medicine.disease_cause Antioxidants 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Phenylketonurias medicine Humans In patient Tyrosine Balance (ability) chemistry.chemical_classification Reactive oxygen species business.industry Infant Newborn 030104 developmental biology chemistry Pediatrics Perinatology and Child Health Female business Reactive Oxygen Species 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Journal of pediatric endocrinologymetabolism : JPEM. 29(6) |
| ISSN: | 2191-0251 |
| Popis: | The balance between reactive oxygen species production and antioxidant activity has an important role in oxidative stress associated diseases such as phenylketonuria (PKU). We aimed in this study to evaluate the possible association between oxidative balance and clinical features of PKU patients.Twenty patients and 50 healthy subjects were selected. Prooxidant-antioxidant balance (PAB) was measured and phenylalanine (Phe), tyrosine (Tyr), Phe/Tyr ratio and hematological indices were determined.A significantly higher PAB value was observed in the patient group (152.0±14.1 HK unit) compared to the controls (88.1±13.88 HK) (pThe serum PAB values were higher in patients with PKU and this was associated with the serum Phe and Tyr and Phe/Tyr ratio. Therefore, because of its low cost and simplicity to perform, PAB value might be considered as a useful monitoring marker among the other tools in these patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|