Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes
| Autor: | Achim A. Jungbluth, Elyn Riedel, Keith Vosseller, Kathleen Wojnoonski, James P. Allison, Chulho Kang, Kevin Larimore, Peter A. Savage |
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| Rok vydání: | 2008 |
| Předmět: |
Male
T cell Receptors Antigen T-Cell alpha-beta Antigen presentation Epitopes T-Lymphocyte Mice Transgenic Streptamer Biology Adenocarcinoma CD8-Positive T-Lymphocytes Autoantigens Epitope Cell Line Histones Mice Lymphocytes Tumor-Infiltrating Antigen Antigens Neoplasm medicine Cytotoxic T cell Animals Antigen-presenting cell Antigen Presentation Multidisciplinary Hybridomas Prostatic Neoplasms T lymphocyte Adoptive Transfer Peptide Fragments medicine.anatomical_structure Immunology |
| Zdroj: | Science (New York, N.Y.). 319(5860) |
| ISSN: | 1095-9203 |
| Popis: | Substantial evidence exists that many tumors can be specifically recognized by CD8 + T lymphocytes. The definition of antigens targeted by these cells is paramount for the development of effective immunotherapeutic strategies for treating human cancers. In a screen for endogenous tumor-associated T cell responses in a primary mouse model of prostatic adenocarcinoma, we identified a naturally arising CD8 + T cell response that is reactive to a peptide derived from histone H4. Despite the ubiquitous nature of histones, T cell recognition of histone H4 peptide was specifically associated with the presence of prostate cancer in these mice. Thus, the repertoire of antigens recognized by tumor-infiltrating T cells is broader than previously thought and includes peptides derived from ubiquitous self antigens that are normally sequestered from immune detection. |
| Databáze: | OpenAIRE |
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