Arteriovenous Malformations—Current Understanding of the Pathogenesis with Implications for Treatment
| Autor: | Khadem Ali, Serena Y. Tan, David A. Stevenson, Gary K. Steinberg, Huy M. Do, Edda Spiekerkoetter, Katharina Schimmel, Joyce M.C. Teng |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
QH301-705.5 Review hereditary hemorrhagic Catalysis Veins Vascular anomaly Inorganic Chemistry Pathogenesis Animals Humans Medicine Molecular Targeted Therapy telangiectasia Biology (General) Physical and Theoretical Chemistry Intensive care medicine arteriovenous malformations QD1-999 Molecular Biology Spectroscopy clinical trials business.industry pathogenesis Organic Chemistry repurposed drugs Arteries Receptor Cross-Talk General Medicine medicine.disease Computer Science Applications vascular anomalies Disease Models Animal Chemistry endothelial cell business High flow |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 9037, p 9037 (2021) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22169037 |
| Popis: | Arteriovenous malformations are a vascular anomaly typically present at birth, characterized by an abnormal connection between an artery and a vein (bypassing the capillaries). These high flow lesions can vary in size and location. Therapeutic approaches are limited, and AVMs can cause significant morbidity and mortality. Here, we describe our current understanding of the pathogenesis of arteriovenous malformations based on preclinical and clinical findings. We discuss past and present accomplishments and challenges in the field and identify research gaps that need to be filled for the successful development of therapeutic strategies in the future. |
| Databáze: | OpenAIRE |
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