Histological evaluation of novel ossicular chain replacement prostheses: an animal study in rabbits

Autor:	Peter Behrens, Gudrun Brandes, Hamidreza Mojallal, Thomas Lenarz, Martin Stieve, Christina Turck, Ilka Krueger
Rok vydání:	2007
Předmět:	Ceramics medicine.medical_specialty Materials science Biocompatibility medicine.medical_treatment Ear Middle Biocompatible Materials Prosthesis Design Prosthesis Animal model Coated Materials Biocompatible medicine Animals Animal study Ear Diseases Petrous Bones Chitosan Ossicular chain Mucous Membrane General Medicine Dental Porcelain Surgery Disease Models Animal Ossicular Prosthesis Durapatite Ossicular Replacement Treatment Outcome medicine.anatomical_structure Otorhinolaryngology Middle ear surgery Granulation Tissue Middle ear Female Rabbits Follow-Up Studies Biomedical engineering
Zdroj:	Acta Oto-Laryngologica. 127:801-808
ISSN:	1651-2251 0001-6489
DOI:	10.1080/00016480601053032
Popis:	The improved biocompatibility of Bioverit II coated with a nanostructured surface shows promising qualities for use in human reconstructive middle ear surgery. In the case of chitosan-hydroxyapatite composite prostheses, further investigations regarding composition of the material, degree of purity and design are necessary before clinical application.The selection of optimal materials for reconstructive middle ear surgery continues to be a problem. In the present study novel materials were tested as total ossicular replacement prostheses (TORPs) in an animal model.Bioverit II coated with a nanostructured surface and chitosan-hydroxyapatite composites were placed in the middle ear of 40 rabbits. Uncoated Bioverit II was used as control. After an implantation period of 28, 84 or 300 days petrous bones were extracted, embedded in epoxy resin and examined by light microscopy.Uncoated and coated Bioverit prostheses revealed a mucosal coverage and a little osseogenic response after 28 days. The results of the coated Bioverit prostheses slightly surpassed those of the plain prostheses. Chitosan-hydroxyapatite composite prostheses were mostly found to be dislocated after 28 days. Formations of granulation tissue and fibrotic capsules were observed around these implants. This reaction could be caused by the instability of the composite material or may be due to impurities present in the chitosan.
Databáze:	OpenAIRE
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