Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division
| Autor: | Hakima Ezzahoini, Daniel Prumbaum, Madhurendra Singh, Lutz Schmitt, Lothar Gremer, Mohammad Reza Ahmadian, Roland P. Piekorz, André Abts, Eyad K. Fansa, Stefan Raunser, Harish C. Thakur, Luitgard Nagel-Steger |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Centrosome
CKAP5 biology Adaptor Protein Complex 3 Clinical Biochemistry Mitosis Microtubule organizing center Spindle Apparatus Biochemistry Clathrin Spindle pole body Protein Structure Tertiary Spindle apparatus Cell biology Microtubule Multigene Family ddc:540 biology.protein Animals Humans Microtubule-Associated Proteins Molecular Biology Cell Division |
| Zdroj: | Biological chemistry 394(11), 1411-1423 (2013). doi:10.1515/hsz-2013-0184 |
| ISSN: | 1437-4315 1431-6730 |
| Popis: | During the mitotic division cycle, cells pass through an extensive microtubule rearrangement process where microtubules forming the mitotic spindle apparatus are dynamically instable. Several centrosomal- and microtubule-associated proteins are involved in the regulation of microtubule dynamics and stability during mitosis. Here, we focus on members of the transforming acidic coiled coil (TACC) family of centrosomal adaptor proteins, in particular TACC3, in which their subcellular localization at the mitotic spindle apparatus is controlled by Aurora-A kinase-mediated phosphorylation. At the effector level, several TACC-binding partners have been identified and characterized in greater detail, in particular, the microtubule polymerase XMAP215/ch-TOG/CKAP5 and clathrin heavy chain (CHC). We summarize the recent progress in the molecular understanding of these TACC3 protein complexes, which are crucial for proper mitotic spindle assembly and dynamics to prevent faulty cell division and aneuploidy. In this regard, the (patho)biological role of TACC3 in development and cancer will be discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|