Efficacy of hydroxychloroquine in hand osteoarthritis
| Autor: | Guo-Qing Yang, Yong-Ping Wang, Qiang-Qiang Li, Huai-Bin Zhang, Wen-Qiang Liang, Ya-Dong Xie |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
hydroxychloroquine Hand Joints MEDLINE Cochrane Library law.invention 03 medical and health sciences 0302 clinical medicine Quality of life Randomized controlled trial law Study Protocol Systematic Review medicine Humans Medical physics pain 030212 general & internal medicine hand function Protocol (science) business.industry Hydroxychloroquine General Medicine Clinical trial osteoarthritis Antirheumatic Agents 030220 oncology & carcinogenesis Meta-analysis Quality of Life business medicine.drug Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Background: Symptoms of hand osteoarthritis result in activity limitations and lower quality of life. Hydroxychloroquine, which has been used successfully in the treatment of many autoimmune diseases, can suppress inflammation and might also be beneficial in hand osteoarthritis. Methods: We plan to perform a systematic review and meta-analysis of randomized clinical trial to determine the symptom-modifying effect of hydroxychloroquine in hand osteoarthritis. We will search PubMed, EMBASE, Cochrane Library, and Web of Science using a comprehensive strategy. The related conference proceedings and reference lists of the included studies will also be checked to identify additional studies. Two reviewers will screen retrieved records, extract information and assess the risk of bias independently. Stata v15.1 software will be used to conduct data synthesis. Results: This study will be submitted to a peer-reviewed journal for publication. Conclusion: We hope it will provide a relatively comprehensive reference for clinical practice and future relevant clinical trials. INPLASY registration number: INPLASY2020110005 |
| Databáze: | OpenAIRE |
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