The Effect of Melatonin on Periodontitis
| Autor: | Peter Celec, Lenka Baňasová, Jakub Janko, Ľubomíra Tóthová, Barbora Konečná, Janka Bábíčková, Paulína Chobodová |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Antioxidant medicine.medical_treatment periodontal disease Physiology medicine.disease_cause Antioxidants lcsh:Chemistry 0302 clinical medicine micro-computed tomography lcsh:QH301-705.5 Spectroscopy Melatonin Communication General Medicine Middle Aged Computer Science Applications medicine.symptom hormones hormone substitutes and hormone antagonists medicine.drug Inflammation Placebo Catalysis Inorganic Chemistry 03 medical and health sciences medicine Animals Humans Physical and Theoretical Chemistry Rats Wistar Periodontitis Saliva Molecular Biology Dental alveolus business.industry Organic Chemistry 030206 dentistry antioxidant treatment medicine.disease Rats Disease Models Animal Oxidative Stress 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 business Oxidative stress Biomarkers Hormone |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 2390, p 2390 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Background: Periodontitis is a chronic disease with a complex etiology that includes bacterial colonization, excessive inflammation, and oxidative stress. The hormone melatonin has antioxidant properties and might contribute to alleviating chronic conditions by reducing oxidative stress. The aim of this study was to analyze the effect of exogenous melatonin on periodontitis in an animal model of the disease as well as in patients with periodontitis. Methods: In rats with ligature-induced periodontitis, melatonin was administered in drinking water for two weeks. In the human study, patients with treatment-resistant periodontitis were asked to rinse their mouths with a solution containing melatonin or placebo every evening for two weeks. Periodontal status as well as salivary markers of oxidative stress were assessed at the end of the study. Results: Neither radiography nor μCT revealed any significant effects of melatonin on alveolar bone loss. Gum recession was the only improved macroscopic measure in rats (p < 0.05). Analysis of salivary markers of oxidative stress revealed no effects of treatment in rats or humans despite clearly elevated melatonin concentrations in melatonin treated groups. Conclusion: Our results do not support the use of melatonin for the treatment of periodontitis. However, the negative outcome is limited by the short duration of the study and the chosen route of application as well as the dose of melatonin. |
| Databáze: | OpenAIRE |
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