Vaccination trials in Australia and Argentina confirm the effectiveness of the EG95 hydatid vaccine in sheep
| Autor: | David Jenkins, Oscar Jensen, Marshall W. Lightowlers, David D. Heath, E Fernandez, D. J. Woollard, J.A Iriarte, Charles G. Gauci |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Helminthiasis Argentina Sheep Diseases Dogs Species Specificity Echinococcosis biology.animal parasitic diseases medicine Helminths Animals Longitudinal Studies Echinococcus granulosus Parasite Egg Count Macropodidae Vaccines Synthetic Sheep biology Australia medicine.disease biology.organism_classification Virology Echinococcus Vaccination Infectious Diseases Parasitology Antigens Helminth Dingo Female |
| Zdroj: | International journal for parasitology. 29(4) |
| ISSN: | 0020-7519 |
| Popis: | Experimental vaccine trials against hydatid disease have been undertaken in sheep using the EG95 recombinant vaccine. Challenge infection was with viable Echinococcus granulosus eggs obtained from a New Zealand isolate (dog/sheep cycle), an Australian isolate (dingo/wallaby cycle) and an Argentine isolate (dog/sheep cycle). Vaccination with EG95 conferred a high degree of protection against challenge with all three parasite isolates (protection range 96-100%). Taken together, the trials demonstrated that 86% of vaccinated sheep were completely free of viable hydatid cysts when examined approximately 1 year after challenge infection. Vaccination reduced the number of viable cysts by 99.3% compared with unvaccinated controls. These results suggest that the EG95 vaccine could have wide applicability as a new tool for use in hydatid control campaigns. |
| Databáze: | OpenAIRE |
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