Maternal transfer of nanoplastics to offspring in zebrafish (Danio rerio): A case study with nanopolystyrene
| Autor: | Richard T. Di Giulio, Rafael Trevisan, Jordan A. Pitt, Jordan S. Kozal, Andrey Massarsky, Edward D. Levin |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine animal structures Environmental Engineering Offspring Glutathione reductase Danio 010501 environmental sciences 01 natural sciences Article Andrology 03 medical and health sciences chemistry.chemical_compound medicine Animals Environmental Chemistry Yolk sac Waste Management and Disposal Zebrafish 0105 earth and related environmental sciences biology Reproductive success Reproduction Embryo Glutathione biology.organism_classification Pollution 030104 developmental biology medicine.anatomical_structure chemistry Larva Nanoparticles Polystyrenes Female Water Pollutants Chemical |
| Zdroj: | Science of The Total Environment. 643:324-334 |
| ISSN: | 0048-9697 |
| DOI: | 10.1016/j.scitotenv.2018.06.186 |
| Popis: | Plastics are ubiquitous anthropogenic contaminants that are a growing concern in aquatic environments. The ecological implications of macroplastics pollution are well documented, but less is known about nanoplastics. The current study investigates the potential adverse effects of nanoplastics, which likely contribute to the ecological burden of plastic pollution. To this end, we examined whether a dietary exposure of adult zebrafish (Danio rerio) to polystyrene nanoparticles (PS NPs) could lead to the transfer of nanoplastics to the offspring, and whether nanoplastics exposure affects zebrafish physiology. Specifically, adult female and male zebrafish (F0 generation) were exposed to PS NPs via diet for one week and bred to produce the F1 generation. Four F1 groups were generated: control (unexposed females and males), maternal (exposed females), paternal (exposed males), and co-parental (exposed males and females). Co-parental PS NP exposure did not significantly affect reproductive success. Assessment of tissues from F0 fish revealed that exposure to PS NPs significantly reduced glutathione reductase activity in brain, muscle, and testes, but did not affect mitochondrial function parameters in heart or gonads. Assessment of F1 embryos and larvae revealed that PS NPs were present in the yolk sac, gastrointestinal tract, liver, and pancreas of the maternally and co-parentally exposed F1 embryos/larvae. Bradycardia was also observed in embryos from maternal and co-parental exposure groups. In addition, the activity of glutathione reductase and the levels of thiols were reduced in F1 embryos/larvae from maternal and/or co-parental exposure groups. Mitochondrial function and locomotor activity were not affected in F1 larvae. This study demonstrates that (i) PS NPs are transferred from mothers to offspring, and (ii) exposure to PS NPs modifies the antioxidant system in adult tissues and F1 larvae. We conclude that PS NPs could bioaccumulate and be passed on to the offspring, but this does not lead to major physiological disturbances. |
| Databáze: | OpenAIRE |
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