Early Events in the Pathogenesis of Avian Salmonellosis
| Autor: | Denise I. Bounous, S. Christine Henderson, Margie D. Lee |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Salmonella typhimurium
Serotype Salmonella animal structures Immunology Inflammation Biology medicine.disease_cause Microbiology Typhoid fever Cell Line Mice Intestinal mucosa medicine Animals Humans Bursa of Fabricius Salmonella Infections Animal Host Response and Inflammation Macrophages medicine.disease biology.organism_classification Virology Enterobacteriaceae Infectious Diseases Lymphatic system Parasitology medicine.symptom Chickens |
| Zdroj: | Infection and Immunity. 67:3580-3586 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.67.7.3580-3586.1999 |
| Popis: | Salmonellae are gastrointestinal pathogens of man and animals. However, strains that are host-specific avian pathogens are often avirulent in mammals, and those which are nonspecific are commensal in poultry. The objective of this study was to determine whether host specificity was exhibited by bacterial abilities to invade epithelial cells or resist leukocyte killing. In this study, leukocytes isolated from humans and chickens were used to kill Salmonella in vitro. Both Salmonella pullorum , an avian-specific serotype, and Salmonella typhimurium , a broad-host-range serotype, were sensitive to killing by polymorphonuclear leukocytes isolated from both species. Both serotypes replicated in cells of the MQ-NCSU avian-macrophage cell line. In contrast, S. pullorum was noninvasive for cultured epithelial Henle 407, chick kidney, chick ovary, and budgerigar abdominal tumor cells. In the bird challenge, however, S. typhimurium rapidly caused inflammation of the intestinal mucosa, but S. pullorum preferentially targeted the bursa of Fabricius prior to eliciting intestinal inflammation. Salmonella serotypes which cause typhoid fever in mice have been shown to target the gut-associated lymphoid tissue. Observations from this study show that S. pullorum initiated a route of infection in chicks comparable to the route it takes in cases of enteric fever. |
| Databáze: | OpenAIRE |
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