Timing of Cervico-Vaginal Cytokine Collection during Pregnancy and Preterm Birth: A Comparative Analysis in the PRINCESA Cohort
| Autor: | Noemi Meraz-Cruz, Betsy Foxman, Brisa N. Sánchez, Miatta A. Buxton, Felipe Vadillo-Ortega, Marie S. O'Neill, Marisol Castillo-Castrejon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
longitudinal data comparative analysis Health Toxicology and Mutagenesis medicine.medical_treatment lcsh:Medicine Inflammation Logistic regression Cohort Studies 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Humans timing of sample collection during pregnancy 030304 developmental biology 0303 health sciences 030219 obstetrics & reproductive medicine Cytokine Measurement integumentary system Obstetrics business.industry Brief Report lcsh:R Public Health Environmental and Occupational Health Infant Newborn preterm birth medicine.disease Confidence interval Cytokine Cross-Sectional Studies inflammation Cohort Gestation Premature Birth Female Pregnancy Trimesters medicine.symptom business |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 18, Iss 3436, p 3436 (2021) International Journal of Environmental Research and Public Health |
| ISSN: | 1661-7827 1660-4601 |
| Popis: | Preterm birth (PTB), defined as birth before 37 completed weeks of gestation, is a major cause of infant morbidity and mortality. Inflammation is an important component in the physiopathologic pathway leading to PTB but results from cross-sectional studies on associations between inflammation, as measured by cytokines, and PTB are inconsistent. Timing of cytokine measurement during pregnancy varies between studies and may contribute to inconsistent findings. We investigated the effects of timing on associations between 16 cervico-vaginal cytokines (Eotaxin, IL-10, IL-12p40, IL-17, IL-1RA, sIL-2rα, IL-1a, IL-1β, IL-2, IL-6, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, and VEGF) and PTB among 90 women throughout pregnancy. We used logistic regression to compare associations between concentrations of cervico-vaginal cytokines from periods in pregnancy and PTB. Trimester 1 cytokines had the strongest positive associations with PTB; for example, OR = 1.76 (95% confidence interval: 1.28, 2.42) for IL-6. Second and third trimester associations were weaker but largely positive. IL-1α was the only cytokine with a negative association (trimesters 2, 3 and overall pregnancy). Strong first trimester associations between cytokines and PTB suggest that measuring cytokines early in pregnancy may hold promise for early identification of PTB risk. Variations in cytokine measurement during pregnancy may contribute to inconsistencies among studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|