Neurodegeneration of lateral habenula efferent fibers after intermittent cocaine administration: Implications for deep brain stimulation
| Autor: | Elad Lax, Efrat Sasson, Ofri Croitoru, Hila Ben-Moshe, Alexander Friedman, Lior Redlus, Yaniv Assaf, Gal Yadid, Einav Sudai, Tamar Blumenfeld-Katzir |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Deep brain stimulation Deep Brain Stimulation medicine.medical_treatment media_common.quotation_subject Efferent Drug-Seeking Behavior Cell Count Self Administration Stimulation Efferent Pathways Extinction Psychological Rats Sprague-Dawley Midbrain Cocaine-Related Disorders Cellular and Molecular Neuroscience Nerve Fibers Cocaine Dopamine Uptake Inhibitors medicine Animals media_common Pharmacology Habenula Dose-Response Relationship Drug medicine.diagnostic_test Addiction Ventral Tegmental Area Neurodegeneration Magnetic resonance imaging medicine.disease Rats Disease Models Animal Extinction (neurology) Nerve Degeneration Conditioning Operant Psychology Neuroscience |
| Zdroj: | Neuropharmacology. 75:246-254 |
| ISSN: | 0028-3908 |
| Popis: | Deep brain stimulation (DBS) is an emerging technique for effective, non-pharmacological intervention in the course of neurological and neuropsychiatric diseases. Several brain targets have been suggested as suitable for DBS treatment of drug addiction. Previously, we showed that DBS of the lateral habenula (LHb) can reduce cocaine intake, facilitate extinction and attenuate drug-induced relapse in rats trained to self-administrate cocaine. Herein, we demonstrated that cocaine self-administration dose-dependently decreased connectivity between the LHb and midbrain, as shown by neurodegeneration of the main LHb efferent fiber, the fasciculus retroflexus (FR). FR degeneration, in turn, may have caused lack of response to LHb stimulation in rats trained to self-administer high-dose cocaine (1.5 mg/kg; i.v.). Furthermore, we show that the micro-structural changes caused by cocaine can be non-invasively detected using magnetic resonance imaging and diffusion tensor imaging. Detection of cocaine-induced alterations in FR anatomy can aid the selection of potential responders to LHb stimulation for treatment of drug addiction. |
| Databáze: | OpenAIRE |
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