The Metabolic Syndrome Predicts Longitudinal Changes in Clock Drawing Test Performance in Older Nondemented Hypertensive Individuals
| Autor: | Evaristo Ettorre, Giovanni Viscogliosi, Iulia Maria Chiriac, Paola Andreozzi |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Gerontology medicine.medical_specialty Blood Pressure Neuroimaging Neuropsychological Tests 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Cognitive Dysfunction Longitudinal Studies 030212 general & internal medicine Cognitive decline Stroke Aged 80 and over Metabolic Syndrome medicine.diagnostic_test Case-control study Cognition Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Blood pressure Case-Control Studies Hypertension Cardiology Female clock drawing test cognitive decline metabolic syndrome Geriatrics and Gerontology Metabolic syndrome Psychology 030217 neurology & neurosurgery |
| Zdroj: | The American Journal of Geriatric Psychiatry. 24:359-363 |
| ISSN: | 1064-7481 |
| DOI: | 10.1016/j.jagp.2015.09.001 |
| Popis: | The present study evaluated the metabolic syndrome (MetS) as independent predictor of 1-year longitudinal changes in cognitive function.104 stroke- and dementia-free older hypertensive subjects were studied. MetS was defined by NCEP ATP-III criteria. Cognitive function was assessed by the Clock Drawing Test (CDT); 1-year changes in cognitive function were expressed as annual changes in CDT performance. Brain magnetic resonance imaging studies (1.5T) were performed.Participants with MetS exhibited greater cognitive decline than those without (-1.78 ± 1.47 versus -0.74 ± 1.44 CDT points, t = 3.348, df = 102, p 0.001). MetS predicted cognitive decline (β = -0.327, t = -3.059, df = 96, p = 0.003) independently of its components, age, baseline cognition, neuroimaging findings, blood pressure levels, and duration of hypertension. With the exception of systolic blood pressure, none of the individual components of MetS explained 1-year changes in CDT performance.MetS as an entity predicted accelerated 1-year decline in cognitive function, assessed by CDT, in a sample of older hypertensive subjects. |
| Databáze: | OpenAIRE |
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