Synthesis of (25R)-26-hydroxycholesterol
| Autor: | Deping Chai, John R. Williams, Dominic Wright |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Pharmacology
Molecular Structure Chemistry medicine.medical_treatment Organic Chemistry Clinical Biochemistry Free-radical reaction Clemmensen reduction Diosgenin Biochemistry Chemical synthesis Hydroxycholesterols Steroid chemistry.chemical_compound Endocrinology Yield (chemistry) medicine Organic chemistry Molecular Biology Deoxygenation |
| Zdroj: | Steroids. 67:1041-1044 |
| ISSN: | 0039-128X |
| Popis: | We describe the synthesis of (25R)-cholest-5-en-3beta,26-diol ((25R)-26-hydroxycholesterol) from diosgenin in four steps in 58% overall, yield via a modified Clemmensen reduction followed by a Barton deoxygenation reaction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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