Bactericidal Antibacterial Mechanism of Plant Synthesized Silver, Gold and Bimetallic Nanoparticles
| Autor: | Oluwatobi S. Oluwafemi, Olufunto T. Fanoro |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Staphylococcus aureus
antibiotic resistance DNA damage lcsh:RS1-441 Pharmaceutical Science Nanoparticle Review 02 engineering and technology Protein oxidation lcsh:Pharmacy and materia medica Metal 03 medical and health sciences bactericidal Escherichia coli metal nanoparticles Bimetallic strip 030304 developmental biology Antibacterial agent 0303 health sciences Chemistry 021001 nanoscience & nanotechnology Combinatorial chemistry visual_art visual_art.visual_art_medium Nanomedicine 0210 nano-technology Antibacterial activity cell membrane |
| Zdroj: | Pharmaceutics, Vol 12, Iss 1044, p 1044 (2020) Pharmaceutics |
| ISSN: | 1999-4923 |
| Popis: | As the field of nanomedicine develops and tackles the recent surge in antibiotic resistance, there is a need to have an in-depth understanding and a synergistic view of research on the effectiveness of a metal nanoparticle (NP) as an antibacterial agent especially their mechanisms of action. The constant development of bacterial resistance has led scientists to develop novel antibiotic agents. Silver, gold and its bimetallic combination are one of the most promising metal NPs because they show strong antibacterial activity. In this review we discuss the mode of synthesis and the proposed mechanism of biocidal antibacterial activity of metal NPs. These mechanisms include DNA degradation, protein oxidation, generation of reactive oxygen species, lipid peroxidation, ATP depletion, damage of biomolecules and membrane interaction. |
| Databáze: | OpenAIRE |
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