Hyaluronan and human endothelial cell behavior
| Autor: | Moira Clerici, Davide Vigetti, Anna Genasetti, Manuela Rizzi, Barbara Bartolini, Francesco Pallotti, Paola Moretto, Alberto Passi, Giancarlo De Luca, Manuela Viola, Eugenia Karousou |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Endothelium
Angiogenesis Biology Biochemistry Extracellular matrix Rheumatology Neoplasms medicine Animals Humans Orthopedics and Sports Medicine Glucuronosyltransferase Hyaluronic Acid Molecular Biology HAS1 Inflammation Neovascularization Pathologic Cell growth Endothelial Cells Cell Biology Cell biology Endothelial stem cell medicine.anatomical_structure Blood Vessels Cytokine secretion Wound healing Hyaluronan Synthases |
| Popis: | Hyaluronan (HA) is the only nonsulphated glycosaminoglycan of extracellular matrix. In mammals HA is synthesised by three homologues HA synthases: HAS1, HAS2, and HAS3. The HA is daily catabolized by the hyaluronidase enzymes to either oligosaccharides or larger polymer. Despite its simple structure, HA is involved in a great number of biological functions, such as cell proliferation and migration, morphogenesis, wound healing, inflammation, angiogenesis, and tumor growth. Moreover, an important biological role is related to HA oligosaccharides that stimulate cytokine secretion and endothelial cell proliferation. Nevertheless no data about HA presence in endothelium are reported in literature. Several studies underline HA involvement in endothelial cell proliferation, migration, new vessels formation, and leucocytes recruitment. We review the role of HA in endothelial cell in normal condition and during vascular injury. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|