Effect of branched chain amino acid enrichment of total parenteral nutrition on nitrogen sparing and clinical outcome of sepsis and trauma: a prospective randomized double blind trial
| Autor: | K. P. De Jong, Peter B. Soeters, C.L.H. van Berlo, D. J. Gouma, J. P. Vente, M.M.J. Rouflart, C. J. van der Linden, M.F. von Meyenfeldt |
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| Přispěvatelé: | Other departments |
| Rok vydání: | 1990 |
| Předmět: |
Male
Nitrogen balance medicine.medical_specialty Calorie Nitrogen Gastroenterology law.invention Sepsis Excretion Postoperative Complications Randomized controlled trial Double-Blind Method law Internal medicine medicine Humans Prospective Studies Prospective cohort study Randomized Controlled Trials as Topic business.industry Multiple Trauma Mortality rate Bacterial Infections medicine.disease Methylhistidines Surgery Parenteral nutrition Female Parenteral Nutrition Total business Energy Metabolism Amino Acids Branched-Chain |
| Zdroj: | British journal of surgery, 77(8), 924-929. John Wiley and Sons Ltd |
| ISSN: | 0007-1323 |
| Popis: | Administration of extra branched chain amino acids (BCAA) has been associated with a nitrogen sparing effect in septic and traumatized patients. Whether nitrogen sparing is associated with decreased morbidity and mortality rates is unknown. We therefore undertook a prospective, randomized, double blind trial investigating the effects of BCAA enrichment of a total parenteral nutrition (TPN) regimen on nitrogen balance, 3-methylhistidine excretion, morbidity as evidenced by disturbances in organ function, severity of sepsis and mortality. One hundred and one patients entered the study; 52 received a standard TPN solution and 49 a BCAA-enriched solution. Both groups received 30 kcal kg−1 body-weight, 15 per cent fat calories and 0·17g nitrogen kg−1 body-weight. In the BCAA-enriched group, patients received 0·56 g BCAAkg−1 body-weight (50·2 per cent BCAA). Standard group patients received 0·18g BCAA kg−1 body-weight (15·6 per cent BCAA). Nitrogen balances and 3-methylhistidine excretion were not significantly different between groups. Although morbidity scores tended to decrease during the study, no difference was observed between groups. Mortality (early or late), sepsis or stress-related, did not differ significantly between groups. We were not able to confirm the reported beneficial effects of BCAA-enriched TPN solutions for use in septic and traumatized patients. |
| Databáze: | OpenAIRE |
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