Penile lichen sclerosus after allogeneic stem cell transplantation
| Autor: | Nigel J. Trendell-Smith, Au Wy, Cheung Mc, Yeung Ck |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Posthitis Graft vs Host Disease Dermatology Biology Lichen sclerosus Atrophy Lymphoplasmacytic Infiltrate Eosinophilic medicine Humans Lung integumentary system Hematopoietic Stem Cell Transplantation Middle Aged Phimosis medicine.disease Transplantation Lichen Sclerosus et Atrophicus surgical procedures operative medicine.anatomical_structure Graft-versus-host disease Chronic Disease |
| Zdroj: | British Journal of Dermatology. 159:470-472 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.1365-2133.2008.08645.x |
| Popis: | Graft-versus-host disease (GVHD) often complicates allogeneic stem cell transplantation (SCT) and affects mainly the gut, liver, lung and skin. The microscopic morphological features of late-phase sclerodermatous chronic GVHD in the skin, namely epidermal atrophy, lymphoplasmacytic infiltration, dense dermal fibrosis and adnexal atrophy, are histologically indistinguishable from those in sporadic systemic sclerosis, morphoea and the related condition of lichen sclerosus. Mucosal orifices including those of the genitourinary system may be severely affected. We present three SCT recipients with chronic GVHD and severe posthitis leading to phimosis requiring surgery. The excised prepuces showed features of lichen sclerosus including epidermal atrophy and a subepidermal zone of eosinophilic, homogeneous and hyalinized collagen above a band-like lymphoplasmacytic infiltrate. These cases add further evidence to support the notion that penile lichen sclerosus should be included within the expanding sclerodermoid spectrum of late-stage cutaneous chronic GVHD. |
| Databáze: | OpenAIRE |
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