Prevalence and clinical association of clonal T-cell expansions in Myelodysplastic Syndrome
| Autor: | D Vendron, Jeffrey S. Painter, Dana E. Rollison, Pearlie K. Epling-Burnette, R Widen, David Boulware, Alan F. List, Fanqi Bai, E. Ku, JianXiang Zou |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Cancer Research T-Lymphocytes T cell Receptors Antigen T-Cell chemical and pharmacologic phenomena Biology Polymerase Chain Reaction T-Lymphocytes Regulatory Antigen Antigens CD medicine Humans Myelodysplastic syndromes T-cell receptor CD28 Hematology Middle Aged NKG2D medicine.disease medicine.anatomical_structure Oncology Karyotyping Myelodysplastic Syndromes Immunology Female Bone marrow CD8 |
| Zdroj: | Leukemia. 21:659-667 |
| ISSN: | 1476-5551 0887-6924 |
| Popis: | Selected patients with Myelodysplastic Syndromes (MDS) are responsive to immunosuppressive therapy, suggesting that hematopoietic suppressive T cells have a pathogenic role in ineffective hematopoiesis. We assessed T-cell receptor (TCR) clonality through combined flow cytometry and molecular analysis of the complementarity determining region (CDR)-3 of the T-cell receptor-Vbeta gene. We identified clonal T cells in 50% of MDS patients (n=52) compared to 5% of age-matched normal controls (n=20). The presence of T-cell clones was not associated with features linked previously to immunosuppression response, including WHO diagnostic category, karyotype, marrow cellularity, IPSS category, sex or age |
| Databáze: | OpenAIRE |
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