Acidosis inhibits rhythmic contractions of human thoracic ducts
| Autor: | Ebbe Boedtkjer, Anders L. Moeller, Donna Briggs Boedtkjer, Vibeke E. Hjortdal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Periodicity Serotonin medicine.medical_specialty Epinephrine Skeletal Muscle Physiology Immunology 030204 cardiovascular system & hematology Thoracic duct lcsh:Physiology Tonic (physiology) 03 medical and health sciences 0302 clinical medicine Interstitial fluid Physiology (medical) Internal medicine Edema medicine Extracellular Humans Cellular and Molecular Conditions Disorders and Treatments Aged Lymphatic Vessels Original Research Acidosis Electrical impedance myography lcsh:QP1-981 Chemistry Muscle Smooth Middle Aged Thorax Adrenergic Agonists Serotonin Receptor Agonists medicine.anatomical_structure Endocrinology Muscle Tonus lymphatics Female Lymph medicine.symptom Muscle Contraction and Relaxation edema 030217 neurology & neurosurgery Muscle Contraction thoracic duct |
| Zdroj: | Physiological Reports, Vol 7, Iss 8, Pp n/a-n/a (2019) Møller, A L, Hjortdal, V E, Bødtkjer, D B & Boedtkjer, E 2019, ' Acidosis inhibits rhythmic contractions of human thoracic ducts ', Physiological Reports, vol. 7, no. 8, e14074 . https://doi.org/10.14814/phy2.14074 Physiological Reports |
| DOI: | 10.14814/phy2.14074 |
| Popis: | Lymph vessels counteract edema by transporting interstitial fluid from peripheral tissues to the large veins and serve as conduits for immune cells, cancer cells, and pathogens. Because edema during inflammation and malignancies is frequently associated with acidosis, we tested the hypothesis that acid‐base disturbances affect human thoracic duct contractions. We studied, by isometric and isobaric myography, the contractile function of human thoracic duct segments harvested with written informed consent from patients undergoing esophageal cancer surgery. Human thoracic ducts produce complex contractile patterns consisting of tonic rises in tension (isometric myography) or decreases in diameter (isobaric myography) with superimposed phasic contractions. Active tone development decreases substantially (~90% at 30 vs. 7 mmHg) at elevated transmural pressure. Acidosis inhibits spontaneous as well as noradrenaline‐ and serotonin‐induced phasic contractions of human thoracic ducts by 70–90% at extracellular pH 6.8 compared to 7.4 with less pronounced effects observed at pH 7.1. Mean tension responses to noradrenaline and serotonin – averaged over the entire period of agonist exposure – decrease by ~50% at extracellular pH 6.8. Elevating extracellular [K+] from the normal resting level around 4 mmol/L increases overall tension development but reduces phasic activity to a level that is no different between human thoracic duct segments investigated at normal and low extracellular pH. In conclusion, we show that extracellular acidosis inhibits human thoracic duct contractions with more pronounced effects on phasic than tonic contractions. We propose that reduced phasic activity of lymph vessels at low pH attenuates lymph propulsion and increases the risk of edema formation. |
| Databáze: | OpenAIRE |
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