In-vitro study of species-specific coagulation differences in animals and humans using rotational thromboelastometry (ROTEM)
| Autor: | Raimund Lechner, Matthias Helm, T Wille, Benedikt Friemert, Hans-Joachim Riesner, M Müller |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Swine Transferability Relative standard deviation Physiology Biology 03 medical and health sciences Animal data Dogs 0302 clinical medicine Species Specificity Animals Humans In vitro study Coagulation (water treatment) 030212 general & internal medicine Animal species Blood Coagulation Sheep Trauma research 030208 emergency & critical care medicine General Medicine Thrombelastography Thromboelastometry Rabbits |
| Zdroj: | Journal of the Royal Army Medical Corps. 165:356-359 |
| ISSN: | 2052-0468 0035-8665 |
| Popis: | Animal tests are conducted in all fields of trauma research, but transferability of these data to humans is limited. For example, it is still unclear which animal species is most similar to humans in terms of physiology of blood coagulation. To improve transferability and raise awareness of the existing differences, we compared human coagulation to coagulation of different animals. Rotational thromboelastometry was used to analyse the blood of pigs, sheep, rabbits and dogs. Animal data were compared with human coagulation based on the number of significant differences of the test parameters and on a descriptive comparison of the extent of relative deviation of the single values. All animal species showed significant differences in coagulation properties when compared with humans. Coagulation parameters of dogs and sheep were on average most similar to humans. However, there is no animal which is most similar to humans concerning all aspects of coagulation. Differences in coagulation between humans and animals are significant. This must be taken into account when transferring animal test data to humans. |
| Databáze: | OpenAIRE |
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