EFFECTS OF DEXAMETHASONE, PREDNISOLONE AND CORTISOL ON THE MAST CELLS AND TISSUE EOSINOPHILS IN RAT GASTRIC MUCOSA
| Autor: | Toimi Räsänen |
|---|---|
| Rok vydání: | 1962 |
| Předmět: |
medicine.medical_specialty
Hydrocortisone Prednisolone Endocrinology Diabetes and Metabolism Dexamethasone Leukocyte Count Endocrinology Internal medicine medicine Gastric mucosa Animals Mast Cells Mast (botany) Histiocyte Chemistry Stomach Histiocytes General Medicine Rats Eosinophils medicine.anatomical_structure Gastric Mucosa medicine.drug |
| Zdroj: | Acta Endocrinologica. 41:432-436 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.0410432 |
| Popis: | Intact rats were injected intramuscularly at 8-hourly intervals with equal amounts, 6×1.0 mg, of dexamethasone (16α-methyl-9α-fluoro-prednisolone) as phosphate, prednisolone (11β,17,21-trihydroxy-pregna-1,4-diene-3,20-dione) and cortisol (11β,17,21-trihydroxy-pregn-4-ene-3,20-dione) both as succinates, all three in water soluble form. The rats were decapitated 4 hours after the last injection and the mucosal mast cells and tissue eosinophilic cells in the body mucosa of the glandular stomach counted. Calculation of the mast cell degranulation and the destruction of tissue eosinophils during the experiment gave the following degranulation coefficients for the degranulation of gastric mucosal mast cells: 0.541 for dexamethasone, 0.177 for prednisolone and 0.088 for cortisol. The corresponding destruction coefficients for the loss of tissue eosinophilia were 0.858, 0.156 and 0.124. It is suggested that the degranulation and destruction coefficients obtained in the investigation are correlated with the catabolic biological activity of the glucocorticoids. |
| Databáze: | OpenAIRE |
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