Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine
| Autor: | Christine Esslinger, Frederike Schirmbeck, Lieuwe de Haan, Susanne Englisch, Franziska Rausch, Sarah Eisenacher, Peter Kirsch, Andreas Meyer-Lindenberg, Mathias Zink, Gabriela Stoessel, Daniela Mier |
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| Přispěvatelé: | ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Adult Psychiatry, APH - Mental Health |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Olanzapine
Adult Male Saccharomyces cerevisiae Proteins medicine.medical_treatment Bioinformatics Amygdala Antipsychotic 03 medical and health sciences 0302 clinical medicine ddc:150 Neural Pathways medicine Humans Pharmacology (medical) Amisulpride Clozapine Biological Psychiatry Original Paper business.industry Functional Neuroimaging Ventral striatum fMRI General Medicine Schizophrenia Obsessive–compulsive Amygdala fMRI Antipsychotic medicine.disease 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure nervous system Schizophrenia Aripiprazole Female business Carrier Proteins 030217 neurology & neurosurgery medicine.drug Antipsychotic Agents Obsessive–compulsive |
| Zdroj: | European archives of psychiatry and clinical neuroscience, 269(8), 931-940. Springer Verlag European Archives of Psychiatry and Clinical Neuroscience |
| ISSN: | 0940-1334 |
| Popis: | Obsessive-compulsive symptoms (OCS) in patients with schizophrenia are a common co-occurring condition, often associated with additional impairments. A subgroup of these patients develops OCS during treatment with second-generation antipsychotics (SGAs), most importantly clozapine and olanzapine. So far, little is known about possible neural mechanism of these SGAs, which seem to aggravate or induce OCS. To investigate the role of SGA treatment on neural activation and connectivity during emotional processing, patients were stratified according to their monotherapy into two groups (group I: clozapine or olanzapine, n = 20; group II: amisulpride or aripiprazole, n = 20). We used an fMRI approach, applying an implicit emotion recognition task. Group comparisons showed significantly higher frequency and severity of comorbid OCS in group I than group II. Task specific activation was attenuated in group I in the left amygdala. Furthermore, functional connectivity from left amygdala to right ventral striatum was reduced in group I. Reduced amygdala activation was associated with OCS severity. Recent literature suggests an involvement of an amygdala-cortico-striatal network in the pathogenesis of obsessive-compulsive disorder. The observed differential activation and connectivity pattern of the amygdala might thus indicate a neural mechanism for the development of SGA-associated OCS in patients with schizophrenia. Further neurobiological research and interventional studies are needed for causal inferences. published |
| Databáze: | OpenAIRE |
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