Lectin Histochemistry of Malignant Fibrohistiocytic Tumors
| Autor: | Takafumi Ueda, Katsuyuki Aozasa, Keishi Matsumoto, Keiro Ono, Teiichi Yamamura, Masahiko Tsujimoto |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty alpha 1-Antichymotrypsin Fibrosarcoma Soft Tissue Neoplasms Pathology and Forensic Medicine Malignant Fibrous Histiocytomas Lectins medicine Humans Histiocyte Aged Histiocytoma Benign Fibrous Staining and Labeling biology Adult patients Histocytochemistry business.industry Lectin Adult case Middle Aged Castor Bean medicine.disease Staining Plants Toxic alpha 1-Antitrypsin biology.protein Immunohistochemistry Female Muramidase Surgery Plant Lectins Anatomy business |
| Zdroj: | The American Journal of Surgical Pathology. 11:257-262 |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/00000478-198704000-00003 |
| Popis: | The staining pattern by Ricinus communis agglutinin (RCA), a lectin used as a good marker for histiocytes, in 24 cases with malignant fibrous histiocytoma (MFH) was studied and compared with that of 12 cases of fibrosarcoma (FS). In 20 (83%) of 24 cases of MFH, varying degrees of RCA binding were observed, whereas only four (33%) of 12 cases of FS were positive. RCA-positive FS included three cases with infantile FS and one adult case with post-radiation FS. Eight adult patients with FS were entirely negative. This positivity rate of RCA binding in MFH was much higher than those of antisera against lysozyme, alpha-1-antitrypsin, and alpha-1-antichymotrypsin previously reported. Seven MFH patients with focal aggregation of RCA-positive benign-appearing (reactive) histiocytes died earlier than the other patients with only scattered RCA-positive histiocytes; 5-year survival rates were 32% and 69%, respectively (p less than 0.05). These findings suggest that RCA reactivity can be used as a potential diagnostic and prognostic marker for MFH. |
| Databáze: | OpenAIRE |
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