Mapping the human middle longitudinal fasciculus through a focused anatomo-imaging study: shifting the paradigm of its segmentation and connectivity pattern
| Autor: | Georgios P. Skandalakis, Foteini Christidi, Spyridon Komaitis, Christos Koutsarnakis, Nikolaos Kelekis, Hugues Duffau, George Stranjalis, Aristotelis V. Kalyvas, Efstratios Karavasilis, Olympia Papakonstantinou, Evangelia Liouta |
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| Přispěvatelé: | Evangelismos Athens General Hospital, National and Kapodistrian University of Athens (NKUA), University of Athens Medical School [Athens], University General Hospital ' Attikon ' [Athens, Greece], Professor Petros S. Kokkalis Hellenic Center for Neurosurgery Research, Neurochirurgie [Hôpital Gui de Chauliac], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier] |
| Rok vydání: | 2019 |
| Předmět: |
Male
Precuneus Superior temporal gyrus 0302 clinical medicine Gyrus Parietal Lobe Neural Pathways MESH: Parietal Lobe MESH: Middle Aged biology General Neuroscience 05 social sciences Brain Middle Aged White Matter Temporal Lobe Diffusion Tensor Imaging medicine.anatomical_structure MESH: Young Adult [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Female Occipital Lobe Anatomy Psychology MESH: Diffusion Tensor Imaging MESH: Occipital Lobe Adult Histology Superior parietal lobule Auditory cortex 050105 experimental psychology Angular gyrus MESH: Brain Young Adult 03 medical and health sciences Fasciculus [INFO.INFO-IM]Computer Science [cs]/Medical Imaging Connectome medicine MESH: Temporal Lobe Humans 0501 psychology and cognitive sciences Brain connectivity MESH: Connectome MESH: Humans MESH: Neural Pathways Temporal pole MESH: Adult biology.organism_classification Auditory function MESH: Male Middle longitudinal fasciculus MESH: White Matter Surgery Neurology (clinical) Occipital lobe MESH: Female Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Brain Structure and Function Brain Structure and Function, Springer Verlag, 2020, 225 (1), pp.85-119. ⟨10.1007/s00429-019-01987-6⟩ |
| ISSN: | 1863-2661 1863-2653 |
| DOI: | 10.1007/s00429-019-01987-6 |
| Popis: | International audience; Τhe middle longitudinal fasciculus (MdLF) was initially identified in humans as a discrete subcortical pathway connecting the superior temporal gyrus (STG) to the angular gyrus (AG). Further anatomo-imaging studies, however, proposed more sophisticated but conflicting connectivity patterns and have created a vague perception on its functional anatomy. Our aim was, therefore, to investigate the ambiguous structural architecture of this tract through focused cadaveric dissections augmented by a tailored DTI protocol in healthy participants from the Human Connectome dataset. Three segments and connectivity patterns were consistently recorded: the MdLF-I, connecting the dorsolateral Temporal Pole (TP) and STG to the Superior Parietal Lobule/Precuneus, through the Heschl's gyrus; the MdLF-II, connecting the dorsolateral TP and the STG with the Parieto-occipital area through the posterior transverse gyri and the MdLF-III connecting the most anterior part of the TP to the posterior border of the occipital lobe through the AG. The lack of an established termination pattern to the AG and the fact that no significant leftward asymmetry is disclosed tend to shift the paradigm away from language function. Conversely, the theory of "where" and "what" auditory pathways, the essential relationship of the MdLF with the auditory cortex and the functional role of the cortical areas implicated in its connectivity tend to shift the paradigm towards auditory function. Allegedly, the MdLF-I and MdLF-II segments could underpin the perception of auditory representations; whereas, the MdLF-III could potentially subserve the integration of auditory and visual information. |
| Databáze: | OpenAIRE |
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