Liver microbubble transit time compared with histology and Child-Pugh score in diffuse liver disease: a cross sectional study
| Autor: | Raffaella Basilico, A. Urbank, A. Lim, Chris J Harvey, M. J. K. Blomley, D. O. Cosgrove, Rolf A. Heckemann, Robert J. Eckersley, N. Patel, Simon D. Taylor-Robinson |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Cirrhosis Cross-sectional study Contrast Media Saline flush Gastroenterology Liver disease Bolus (medicine) Polysaccharides Fibrosis Internal medicine Biopsy Humans Medicine Prospective Studies Prospective cohort study Aged Analysis of Variance medicine.diagnostic_test business.industry Liver Diseases Ultrasonography Doppler Middle Aged medicine.disease Microspheres Cross-Sectional Studies Liver Female Radiology business |
| Zdroj: | Gut. 52:1188-1193 |
| ISSN: | 0017-5749 |
| Popis: | Background: A previous pilot study showed that early arrival time of a microbubble in a hepatic vein is a sensitive indicator of cirrhosis. Aim: To see if this index can also grade diffuse liver disease. Patients: Thirty nine fasted patients with histologically characterised disease were studied prospectively. Nine patients had no evidence of liver fibrosis, 10 had fibrosis without cirrhosis, and 20 had cirrhosis (five Child’s A, seven Child’s B, and eight Child’s C). Methods: Bolus injections of a microbubble (Levovist; Schering, Berlin) were given intravenously, followed by a saline flush. Time intensity curves of hepatic vein and carotid artery spectral Doppler signals were analysed. Hepatic vein transit time (HVTT) was calculated as the time after injection at which a sustained signal increase >10% of baseline was seen. Carotid delay time (CDT) was calculated as the difference between carotid and hepatic vein enhancement. Results: Diagnostic studies were achieved in 38/39 subjects. Both HVTT and CDT became consistently shorter with worsening disease, as follows (means (SD)): HVTT: no fibrosis 44 (25) s, fibrosis 26 (8) s, Child’s A 21 (1) s, Child’s B 16 (3) s, and Child’s C 16 (2) s; CDT: no fibrosis 31 (29) s, fibrosis 14 (6) s, Child’s A 8 (1) s, Child’s B 4 (4) s, and Child’s C 3 (3) s. These differences were highly significant (p |
| Databáze: | OpenAIRE |
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