Low-dose arsenic trioxide combined with aclacinomycin A synergistically enhances the cytotoxic effect on human acute myelogenous leukemia cell lines by induction of apoptosis

Autor:	Mingwan Zhang, Guangyang Weng, Xiaochun Bai, Wenfang Yi, Ziwen Guo, Jing Wang, Dafa Qiu, Xin He, Xiaojun Xu, Kun-Yuan Guo, Yongbin Ye, Huiqing He, Ruiqing Zhou
Rok vydání:	2015
Předmět:	Cancer Research Cell Survival Gene Expression Antineoplastic Agents Apoptosis HL-60 Cells Pharmacology Arsenicals chemistry.chemical_compound Myelogenous Arsenic Trioxide Cell Line Tumor medicine Humans Cytotoxic T cell Arsenic trioxide Aclarubicin Cell Proliferation Dose-Response Relationship Drug business.industry Cell Cycle Myeloid leukemia Drug Synergism Oxides Hematology Cell cycle XIAP Leukemia Myeloid Acute Oncology chemistry Apoptosis Regulatory Proteins business medicine.drug
Zdroj:	Leukemia & Lymphoma. 56:3159-3167
ISSN:	1029-2403 1042-8194
DOI:	10.3109/10428194.2015.1011155
Popis:	Acute myeloid leukemia (AML) is a common disorder in the elderly. Although remarkable progress has been made over recent decades, the outcome remains poor. Thus, the development of a more effective method to overcome this problem is necessary. In this study, we aimed to investigate the synergistic cytotoxic effect of low-dose arsenic trioxide (As2O3) combined with aclacinomycin A (ACM) on the human AML cell lines KG-1a and HL-60, and to clarify the underlying mechanism. Results showed that As2O3 combined with ACM exerted a synergistic cytotoxic effect by activation of the apoptosis pathway. Additionally, we found that the combination treatment decreased Bcl-2, c-IAP and XIAP expression but increased SMAC and caspase-3 expression more significantly than the single drug treatments. Furthermore, combination index (CI) values were < 1 in all matched combination groups. Additional evaluation of As2O3 combined with ACM as a potential therapeutic benefit for AML seems warranted.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15646360e8ea7243fcb9efd9355b960f https://doi.org/10.3109/10428194.2015.1011155 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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