PREVALENCE OF AGE, GENDER AND TYPE OF GASTRO OESOPHAGEAL JUNCTION MALIGNANCY IN A TERTIARY CARE HOSPITAL

Autor: Rajesh Mithalavalaram Raghavan, Sasi Malayan Parambil, Jithin Eldo Paul
Rok vydání: 2016
Předmět:
Zdroj: Journal of Evidence Based Medicine and Healthcare, Vol 3, Iss 24, Pp 1079-1082 (2016)
ISSN: 2349-2570
2349-2562
DOI: 10.18410/jebmh/2016/248
Popis: BACKGROUND Cancer of the oesophagus is the ninth most common malignancy, causes 2% of all cancer-related deaths worldwide. This study was aimed to determine the type of malignancy more common in gastro oesophageal junction as well as to know the age and gender distribution of malignancy. METHODS Longitudinal study was done by including all the diagnosed cases of carcinoma of gastro oesophageal junction who had undergone oesophagectomy. The resected specimen of the subset of patients with adenocarcinoma was examined for the presence of intestinal metaplasia using haematoxylin and eosin stain. RESULTS A total of 36 patients were studied. Among the 36 cases, 21 cases (58.33%) were squamous cell carcinoma with 13 patients (61.9%) between 50 years and 70 years of age and rest 15 cases (41.66%) were adenocarcinoma with 8 patients (53.3%) between 50 to 60 years of age. All the adenocarcinomas were presented in late stage (T3 or T4), 60% with lymph node metastasis and 20% of patients had intestinal metaplasia. Among the patients with squamous cell carcinoma, 62% presented with T3 disease and 33% presented with T2 disease and only 19% of patients had lymph node metastasis. CONCLUSION Among the malignancy at the gastro oesophageal junction, squamous cell carcinoma with female dominance was more common than adenocarcinoma with male dominance. Most of the cases were with well differentiated tumours presenting at a late stage of the disease either T3 or T4 with low incidence of lymph node metastasis. Adenocarcinoma showed a low incidence of specialized intestinal metaplasia.
Databáze: OpenAIRE
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