Diagnostic accuracy of high-risk HPV DNA genotyping for primary cervical cancer screening and triage of HPV-positive women, compared to cytology: preliminary results of the PIPAVIR study
| Autor: | Nikolaos Maglaveras, Oliver Boecher, Andreas M. Kaufmann, Athena Tsertanidou, Ingke Hagemann, Eleftherios Angelis, Erwin Soutschek, Theodoros Agorastos, Alkmini Skenderi, Kimon Chatzistamatiou, Stamatia Angelidou, Pidder Jansen-Duerr, Vasilis Kilintzis, Isabel Koch, Evangelia Katsiki, Theodoros Moysiadis, Irini Lekka |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Genotype Uterine Cervical Neoplasms Cervical cancer screening 03 medical and health sciences 0302 clinical medicine Cytology medicine Humans Genotyping Papillomaviridae Early Detection of Cancer Colposcopy Gynecology Human papillomavirus 16 030219 obstetrics & reproductive medicine medicine.diagnostic_test Human papillomavirus 18 business.industry HPV Positive Obstetrics and Gynecology General Medicine Middle Aged Triage female genital diseases and pregnancy complications 030220 oncology & carcinogenesis Liquid-based cytology DNA Viral Female business Ascus |
| Zdroj: | Archives of gynecology and obstetrics. 295(5) |
| ISSN: | 1432-0711 |
| Popis: | The purpose of the presented PIPAVIR (persistent infections with human papillomaviruses; http://www.pipavir.com ) subanalysis is to assess the performance of high-risk (hr) HPV-DNA genotyping as a method of primary cervical cancer screening and triage of HPV positive women to colposcopy compared to liquid-based cytology (LBC) in an urban female population. Women, aged 30–60, provided cervicovaginal samples at the Family-Planning Centre, Hippokratio Hospital of Thessaloniki, Greece, and the Department of Gynecology and Obstetrics in Mare Klinikum, Kiel, Germany. Cytology and HPV genotyping was performed using LBC and HPV Multiplex Genotyping (MPG), respectively. Women positive for cytology [atypical squamous cells of undetermined significance (ASC-US) or worse] or hrHPV were referred for colposcopy. Among 1723/1762 women included in the final analysis, hrHPV and HPV16/18 prevalence was 17.7 and 9.6%, respectively. Cytology was ASCUS or worse in 7.6%. Cervical Intraepithelial Neoplasia grade 2 or worse (CIN2+) was detected in 28 women (1.6%). Sensitivity of cytology (ASCUS or worse) and HPV DNA testing for the detection of CIN2+ was 50.0 and 100%, and specificity was 94.49 and 85.49%, respectively. The screening approach according to which only women positive for HPV16/18 and for hrHPV(non16/18) with ASCUS or worse were referred to colposcopy presented 78.57% sensitivity and 13.17% positive predictive value (PPV). HPV testing represents a more sensitive methodology for primary cervical cancer screening compared to cytology. For triage of HPV positive women to colposcopy, partial HPV genotyping offers better sensitivity than cytology, at the cost of higher number of colposcopies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink