Hippocampo-cortical coupling mediates memory consolidation during sleep
| Autor: | Gabrielle Girardeau, Nicolas Maingret, Ralitsa Todorova, Michaël B. Zugaro, Marie Goutierre |
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| Přispěvatelé: | Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Prefrontal Cortex Hippocampus Hippocampal formation 03 medical and health sciences 0302 clinical medicine Memory Encoding (memory) Biological neural network Animals Rats Long-Evans ComputingMilieux_MISCELLANEOUS Memory Consolidation Behavior Animal Recall Consolidation (soil) General Neuroscience Electroencephalography Delta wave 030104 developmental biology Mental Recall Memory consolidation Sleep Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature Neuroscience Nature Neuroscience, Nature Publishing Group, 2016, 19 (7), pp.959-964. ⟨10.1038/nn.4304⟩ |
| ISSN: | 1546-1726 1097-6256 |
| Popis: | Memory consolidation is thought to involve a hippocampo-cortical dialog during sleep to stabilize labile memory traces for long-term storage. However, direct evidence supporting this hypothesis is lacking. We dynamically manipulated the temporal coordination between the two structures during sleep following training on a spatial memory task specifically designed to trigger encoding, but not memory consolidation. Reinforcing the endogenous coordination between hippocampal sharp wave-ripples, cortical delta waves and spindles by timed electrical stimulation resulted in a reorganization of prefrontal cortical networks, along with subsequent increased prefrontal responsivity to the task and high recall performance on the next day, contrary to control rats, which performed at chance levels. Our results provide, to the best of our knowledge, the first direct evidence for a causal role of a hippocampo-cortical dialog during sleep in memory consolidation, and indicate that the underlying mechanism involves a fine-tuned coordination between sharp wave-ripples, delta waves and spindles. |
| Databáze: | OpenAIRE |
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