Chronic converting enzyme inhibition normalizes QT interval in aging rats
| Autor: | R. Fazan Júnior, E. Ferreira Neto, Helio Cesar Salgado, V.J. Dias da Silva |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Aging Captopril Physiology Immunology RR interval Biophysics Angiotensin-Converting Enzyme Inhibitors Biochemistry QT interval Electrocardiography QRS complex Heart Rate Internal medicine medicine Animals cardiovascular diseases Rats Wistar General Pharmacology Toxicology and Pharmaceutics PR interval Beneficial effects lcsh:QH301-705.5 Analysis of Variance lcsh:R5-920 biology business.industry General Neuroscience Angiotensin-converting enzyme Cell Biology General Medicine Electrocardiogram Rats Enzyme inhibition Endocrinology lcsh:Biology (General) biology.protein business lcsh:Medicine (General) medicine.drug |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 35, Iss 9, Pp 1025-1031 (2002) Scopus-Elsevier Brazilian Journal of Medical and Biological Research v.35 n.9 2002 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Volume: 35, Issue: 9, Pages: 1025-1031, Published: SEP 2002 |
| ISSN: | 0034-7310 |
| Popis: | The aim of the present study was to investigate the effects of converting enzyme inhibition by captopril on ECG parameters in aged rats. Four-month-old male rats received captopril dissolved in tap water (0.5 mg/l) or tap water for 2 or 20 months. At the end of treatment, under anesthesia, RR and PR interval, P wave and QRS duration, QT and corrected QT interval were measured in all animals. On the following day, chronic ECG (lead II) recordings were performed to quantify supraventricular (SVPB) or ventricular premature beats (VPB). After sacrifice, the hearts were removed and weighed. RR interval was similar in young and untreated aged rats, but significantly larger in aged rats treated with captopril. P wave and QRS length did not differ among groups. PR interval was significantly larger in old than in young rats and was not affected by captopril. Corrected QT interval was larger in aged than in young rats (117 +/- 4 vs 64 +/- 6 ms, P0.05) and was reduced by captopril (71 +/- 6 ms, P0.05). VPB were absent in young rats and highly frequent in untreated old animals (8.4 +/- 3.0/30 min). Captopril significantly reduced VPB in old rats (0.3 +/- 0.1/30 min, P0.05). The cardiac hypertrophy found in untreated aged rats was prevented by captopril (3.44 +/- 0.14 vs 3.07 +/- 0.10 mg/g, P0.05). The beneficial effects of angiotensin converting enzyme inhibition on the rat heart during the aging process are remarkable. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|