Biological Signatures of Alzheimer's Disease
Autor: | Sharad Wakode, Poornima Sharma, Faizana Fayaz, Anjali Sharma, Faheem Hyder Pottoo |
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Rok vydání: | 2019 |
Předmět: |
Apolipoprotein E
Male Pathology medicine.medical_specialty Tau protein Plaque Amyloid tau Proteins 01 natural sciences Protein Aggregation Pathological White matter Apolipoproteins E Sex Factors Alzheimer Disease Drug Discovery medicine Genetics Dementia Humans Senile plaques Perivascular space Amyloid beta-Peptides biology Microglia business.industry Age Factors Extracellular Fluid Neurofibrillary Tangles General Medicine medicine.disease Axons 0104 chemical sciences 010404 medicinal & biomolecular chemistry Cerebral Amyloid Angiopathy Oligodendroglia Oxidative Stress medicine.anatomical_structure Microvessels biology.protein Female Cerebral amyloid angiopathy business Glymphatic System |
Zdroj: | Current topics in medicinal chemistry. 20(9) |
ISSN: | 1873-4294 |
Popis: | Alzheimer’s disease (AD) is the most prevalent and severe neurodegenerative disease affecting more than 0.024 billion people globally, more common in women as compared to men. Senile plaques and amyloid deposition are among the main causes of AD. Amyloid deposition is considered as a central event which induces the link between the production of β amyloid and vascular changes. Presence of numerous biomarkers such as cerebral amyloid angiopathy, microvascular changes, senile plaques, changes in white matter, granulovascular degeneration specifies the manifestation of AD while an aggregation of tau protein is considered as a primary marker of AD. Likewise, microvascular changes, activation of microglia (immune defense system of CNS), amyloid-beta aggregation, senile plaque and many more biomarkers are nearly found in all Alzheimer’s patients. It was seen that 70% of Alzheimer’s cases occur due to genetic factors. It has been reported in various studies that apolipoprotein E(APOE) mainly APOE4 is one of the major risk factors for the later onset of AD. Several pathological changes also occur in the white matter which include dilation of the perivascular space, loss of axons, reactive astrocytosis, oligodendrocytes and failure to drain interstitial fluid. In this review, we aim to highlight the various biological signatures associated with the AD which may further help in discovering multitargeting drug therapy. |
Databáze: | OpenAIRE |
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