Comparison of SPE, IFE, and FLC in Monitoring Patients with Multiple Myeloma After Autologous Stem Cell Transplantation
| Autor: | Feiran Gong, Jia-Zi Zhou, Li-Jun Dai, Huirong Chang, Zi-Ling Zhu, Yu-Feng Feng, Wei Li, Depei Wu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Immunofixation
Oncology medicine.medical_specialty Pathology Pharmacology toxicology Biophysics Sensitivity and Specificity Transplantation Autologous Biochemistry Autologous stem-cell transplantation hemic and lymphatic diseases Internal medicine Screening programs Humans Medicine Multiple myeloma Immunoassay Hematologic Tests integumentary system biology medicine.diagnostic_test business.industry Blood Proteins Cell Biology General Medicine Blood Protein Electrophoresis medicine.disease Serum protein electrophoresis biology.protein Multiple Myeloma business Stem Cell Transplantation |
| Zdroj: | Cell Biochemistry and Biophysics. 73:643-647 |
| ISSN: | 1559-0283 1085-9195 |
| DOI: | 10.1007/s12013-015-0655-z |
| Popis: | Conventionally, serum protein electrophoresis (SPE) and serum immunofixation electrophoresis (IFE) are used as primary methods to diagnose and monitor multiple myeloma (MM). Recently, serum-free light chain (FLC) assay has been incorporated into hematological screening programs for myeloma. The purpose of this study is to compare the performance of the three methods in monitoring MM patients after autologous stem cell transplantation (ASCT). SPE, serum IFE and serum FLC assay were performed on 38 MM patients who underwent ASCT. In total, four patients had unexpected protein bands (UPBs) and 13 patients had relapsed after ASCT. Our results indicate that IFE is more sensitive than SPE and FLC assay in detection of UPBs and relapse. The results of IFE may provide useful information in advance of patient relapse. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink