Skewed X-Chromosome Inactivation in Women Affected by Alzheimers Disease
| Autor: | Elka Stefanova, Vesna Mandusic, Ana Bozovic, Biljana Spremo-Potparević, Andrea Čabarkapa, Lada Zivkovic, Radoslav Davidovic, Vladan Bajic |
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| Rok vydání: | 2015 |
| Předmět: |
Aneuploidy
Biology Real-Time Polymerase Chain Reaction X-inactivation 03 medical and health sciences X-chromosome skewing 0302 clinical medicine Alzheimer Disease X Chromosome Inactivation medicine Humans Epigenetics Lymphocytes aneuploidy Promoter Regions Genetic Skewed X-inactivation X chromosome 030304 developmental biology Aged X-chromosome 0303 health sciences General Neuroscience Chromosome General Medicine Methylation DNA Methylation Middle Aged Alzheimer's disease medicine.disease Androgen receptor Psychiatry and Mental health Clinical Psychology Alzheimers disease methylation specific qPCR Receptors Androgen Immunology Female Geriatrics and Gerontology 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimers Disease |
| Popis: | X-chromosome instability has been a long established feature in Alzheimer's disease (AD). Premature centromere division and aneuploidy of the X-chromosome has been found in peripheral blood lymphocytes and neuronal tissue in female AD patients. Interestingly, only one chromosome of the X pair has been affected. These results raised a question, "Is the X-chromosome inactivation pattern altered in peripheral blood lymphocytes of women affected by AD?" To address this question, we analyzed the methylation status of androgen receptor promoter which may show us any deviation from the 50 : 50% X inactivation status in peripheral blood lymphocytes of women with AD. Our results showed skewed inactivation patterns (>90%). These findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women. |
| Databáze: | OpenAIRE |
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