Biophysical adaptation of the theory of photo-induced phase transition: model of cooperative gating of cardiac ryanodine receptors
| Autor: | Olga Solovyova, V S Markhasin, M.P. Philipiev, A. S. Moskvin |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
History
medicine.medical_specialty Phase transition Ryanodine receptor Endoplasmic reticulum Cardiac muscle chemistry.chemical_element Gating Calcium musculoskeletal system Computer Science Applications Education Endocrinology medicine.anatomical_structure chemistry Internal medicine cardiovascular system medicine Biophysics Intracellular |
| Zdroj: | Journal Of Physics Conference Series |
| Popis: | Theory of photo-induced phase transitions has been adapted to describe the cooperative dynamics of the lattice of ryanodine receptors/channels (RyR) in cardiac muscle which regulate the release of the intracellular activator calcium from calcium stores in the sarcoplasmic reticulum (SR) by a process of Ca2+-induced Ca2+ release (CICR). We introduce two main degrees of freedom for RyR channel, fast electronic and slow conformational ones. The RyR lattice response to the L-type channel triggering evolves due to a nucleation process with a step-by-step domino-like opening of RyR channels. Typical mode of RyR lattice functioning in a CICR process implies the fractional release with a robust termination due to the depletion of SR with a respective change in effective conformational strain. The SR overload leads to an unconventional auto-oscillation regime with a spontaneous calcium release. The model is believed to consistently describe the main features of CICR, that is its gradedness, coupled gating, irreversibility, inactivation/adaptation, and spark termination. |
| Databáze: | OpenAIRE |
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