Beta and delta cells of the human adenohypophysis: their response to adrenocortical disorders
| Autor: | F. Marguerite Hill, John W. Dawson, Calvin Ezrin, John G. Humphrey, Heidi E. Swanson |
|---|---|
| Rok vydání: | 1959 |
| Předmět: |
Adrenal Cortex Diseases
medicine.medical_specialty Pituitary gland Somatostatin-Secreting Cells Endocrinology Diabetes and Metabolism Clinical Biochemistry Alpha (ethology) Basophil Biology Biochemistry Cushing syndrome Endocrinology Pituitary Gland Anterior Internal medicine medicine Adrenal insufficiency Humans Delta cell Biochemistry (medical) medicine.disease medicine.anatomical_structure Addison's disease Pituitary Gland Adrenal Cortex Glucocorticoid medicine.drug |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 19(6) |
| ISSN: | 0021-972X |
| Popis: | Five types of cells can be distinguished in the human adenohypophysis by the iron-PAS technique; alpha cells (acidophils), beta and delta cells (two types of basophils), gamma cells (a heterogenous group of lightly PAS-positive cells), and chromophobes (small nongranular cells). Cell counts were performed on the hypophysis in 7 cases of Addison's disease, 3 cases of Cushing's syndrome, and 14 patients who had received large doses of glucocorticoids. The results were compared to the counts in a control group of 71 subjects without endocrine disease. In adrenal insufficiency the proportion of Crooke-Russell gamma cells was increased, and that of alpha and beta cells was decreased. Conversely, in states of prolonged glucocorticoid excess the proportion of gamma cells was decreased, and that of alpha cells was increased. Many beta cells were hyalinized, although their total percentage remained unchanged. With either adrenal insufficiency or excess of glucocorticoids, delta cells often persisted at a ... |
| Databáze: | OpenAIRE |
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