Monitoring of Adverse Drug Reaction-Related Parameters in Children, Youth, and Young Adults Prescribed Antipsychotic Drugs by General Practitioners
| Autor: | Minjon, Lenneke, van den Ban, Els, Bazelier, Marloes T, Lalmohamed, Arief, Egberts, Toine C G, Heerdink, Eibert R, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology |
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| Přispěvatelé: | Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Drug-Related Side Effects and Adverse Reactions medicine.medical_treatment Primary health care Young Adult General Practitioners Medicine Humans Pharmacology (medical) Young adult Adverse effect Antipsychotic Child Retrospective Studies drug monitoring youth business.industry Infant Newborn Infant antipsychotic agents medicine.disease primary health care Psychiatry and Mental health Child Preschool Pediatrics Perinatology and Child Health adverse effects Female business Adverse drug reaction Follow-Up Studies |
| Zdroj: | Journal of Child and Adolescent Psychopharmacology, 32(1), 36. Mary Ann Liebert inc Journal of Child and Adolescent Psychopharmacology, 32(1), 36. Mary Ann Liebert Inc. |
| ISSN: | 1044-5463 |
| Popis: | Objective: The aim of the study was to assess monitoring of adverse drug reaction (ADR)-related parameters in children, youth, and young adults treated with second-generation antipsychotic drugs (SGAs) prescribed by general practitioners (GPs). Methods: This retrospective follow-up study included children, youth, and young adults aged 0 - 24 years, who had an initial prescription of an SGA recorded in the Clinical Practice Research Datalink between 2000 and 2017, and who were prescribed an SGA more than once for a duration of at least 6 months. It included an assessment of which ADR-related physical parameters (weight, height, body-mass index, waist circumference, pulse, blood pressure, and heart examination) and laboratory parameters (glucose, HbA1c, lipids, and prolactin) were monitored in children, youth, and young adults at least once every 6-month period, stratified by sex, age categories, and calendar years. Results: In total, 7006 patients were included and the mean duration of follow-up was 1.6 years. Monitoring frequencies of all parameters were below 25%. Blood pressure and weight were monitored in 23.6% and 23.4%, respectively, of all children, youth, and young adults during the first half year; waist circumference was monitored in 0.2%. Females were monitored more often than males, some differences between age categories were observed, and monitoring frequencies increased after 2000, but did not exceed 35% in any year. Conclusion: Monitoring frequencies of ADR-related parameters in children, youth, and young adults treated with SGAs prescribed by a GP were low. Monitoring in primary care should be improved to enable a better evaluation of the benefit-risk balance during antipsychotic drug therapy. |
| Databáze: | OpenAIRE |
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