The Effect of Biocomposite Screws on Bone Regeneration in a Rat Osteoporosis Model
| Autor: | Sang Ryong Jeon, Kyoung Hyo Choi, Ji Yeon Kim, Je Hoon Jeong, Eun-Sun Jin, JoongKee Min, Minsu Lee, Bora Lee |
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| Rok vydání: | 2017 |
| Předmět: |
Calcium Phosphates
0301 basic medicine endocrine system medicine.medical_specialty Bone Regeneration Bone Screws Osteoporosis H&E stain Dentistry 03 medical and health sciences Polylactic Acid-Polyglycolic Acid Copolymer Bone Density Internal medicine polycyclic compounds medicine Animals Trichrome stain Lactic Acid Rats Wistar Bone regeneration Bone mineral Tibia business.industry X-Ray Microtomography medicine.disease surgical procedures operative 030104 developmental biology Endocrinology Ovariectomized rat Female Surgery Neurology (clinical) Implant Biocomposite business Polyglycolic Acid hormones hormone substitutes and hormone antagonists |
| Zdroj: | World Neurosurgery. 106:964-972 |
| ISSN: | 1878-8750 |
| Popis: | Objective To evaluate the efficacy of biocomposite screws used in ovariectomy (OVX)-induced osteoporotic rats. Methods Twenty-four female Wistar rats (250–300 g, 12 weeks old) were divided into 4 groups: sham group (control), OVX-induced osteoporosis group (OVX), OVX and biodegradable poly(lactic- co -glycolic acid) (PLGA) without tricalcium phosphate (β-TCP) screw insertion group (OVX/BSR), and OVX and biocomposite (PLGA with β-TCP) screw insertion group (OVX/CSR). Three groups underwent bilateral OVX, and of these, 2 groups had 2 different types of screw inserted at the proximal tibia. At 25 weeks after OVX, the bilateral tibias were extracted. The extracted tibiae were scanned by ex vivo micro-computed tomography (CT) and stained with hematoxylin and eosin (H&E) and with Masson's trichrome stain for pathological assessment. Results Compared with the ovariectomized groups, the control group had the highest values for bone mineral density (BMD), bone volume (BV)/total volume (TV), and trabecular number (Tb.N) and the lowest values for trabecular thickness (Tb.Th) and trabecular separation (Tb.Sp). In the pairwise comparison among ovariectomized groups, the OVX/CSR group had significantly higher BMD, BV/TV, and Tb.N values than the other 2 groups (OVX and OVX/BSR) and significantly lower Tb.Sp. Micro-CT scans showed clear evidence of new trabecular formation near the screw insertion site in the OVX/CSR group only. Analyses of H&E- and Masson's trichrome–stained sections showed more and thicker trabecular bone around the implant in the OVX/CSR group compared with the OVX and OVX/BSR groups. Conclusions Biocomposite screws can improve local bone quality and facilitate osteoconductivity in an osteoporotic rat model. |
| Databáze: | OpenAIRE |
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