Prenatal stress promotes insulin resistance without inflammation or obesity in C57BL/6J male mice
| Autor: | Ana María Genaro, Adriana Laura Burgueño, María Paula Marcone, Yamila Raquel Juarez, Sofía Quiroga, María Agustina Vidal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Physiology Adipose tissue Carbohydrate metabolism ESTRES PRENATAL RESISTENCIA A LA INSULINA Mice Behavioral Neuroscience Insulin resistance Pregnancy Internal medicine medicine Animals Insulin Glucose homeostasis Obesity Inflammation Adiponectin Endocrine and Autonomic Systems business.industry Leptin medicine.disease TEJIDO ADIPOSO Mice Inbred C57BL Psychiatry and Mental health Neuropsychology and Physiological Psychology Endocrinology Adipose Tissue Prenatal stress HIGADO EXPRESION GENICA PROGRAMACION FETAL Female Resistin Insulin Resistance business Stress Psychological |
| Zdroj: | Stress: The International Journal on the Biology of Stress Vol.24, No.6, 2021 Repositorio Institucional (UCA) Pontificia Universidad Católica Argentina instacron:UCA |
| Popis: | Fil: Quiroga, Sofia. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina Fil: Quiroga, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Juárez, Yamila Raquel. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina Fil: Juárez, Yamila Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Marcone, María Paula. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina Fil: Marcone, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Vidal, María Agustina. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina Fil: Vidal, María Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Genaro, Ana María. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina Fil: Genaro, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Burgueño, Adriana Laura. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina Fil: Burgueño, Adriana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Abstract: During gestation, stress exposure increases the risk of developing cognitive and physiological alterations in either the long or short term. Among them, metabolic alterations have been described. Adipose tissue is responsible for the secretion of several factors involved in controlling body weight and energy expenditure, the regulation of insulin sensitivity, and the development of inflammation, among others. Moreover, the liver regulates glucose homeostasis and lipid metabolism, playing an essential role in developing insulin resistance. In this work, we analyzed if prenatal stress leads to alterations in metabolism and the relationship between these alterations and gene expression in the adipose tissue and the liver. Prenatal stress-exposed animals developed disturbances in the glucose and insulin response curve, showing in both tests higher glycemia than the control group. However, they did not exhibit increased body weight. At the same time, in the adipose tissue, we observed an increase in mRNA expression of Leptin and Resistin and a decrease in Adiponectin. In the liver, we observed a lower mRNA expression of several genes involved in glucose metabolism and fatty acid oxidation, such as Sirt1, Pgc1α, Pparα, among others. In both tissues, we observed a lower expression of inflammatory genes. These results suggest that prenatal stress exposure produces insulin resistance at both physiological and molecular levels without pro-inflammatory signaling or obesity. |
| Databáze: | OpenAIRE |
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