Secondary hemophagocytic lymphohistiocytosis possibly induced by interferon beta-1a therapy
| Autor: | Marco A. Cimmino, Claudio Cosso, R Cosso |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Secondary Hemophagocytic Lymphohistiocytosis
lcsh:Internal medicine Multiple Sclerosis Hepatosplenomegaly lcsh:Medicine Lymphohistiocytosis Hemophagocytic Rheumatology Adjuvants Immunologic medicine Humans lcsh:RC31-1245 Hemophagocytic lymphohistiocytosis biology business.industry lcsh:R Interferon beta-1a Interferon-beta Hypofibrinogenemia Middle Aged medicine.disease Ferritin Interferon Hemophagocytosis Macrophage activation syndrome Hemophagocytic lymphohistiocytosis Multiple sclerosis Macrophage activation syndrome Immunology biology.protein Female Hemophagocytosis medicine.symptom business medicine.drug |
| Zdroj: | Reumatismo, Vol 65, Iss 5, Pp 253-255 (2013) |
| Popis: | A 57-year old woman with a history of multiple sclerosis, treated with interferon beta-1a in the last 5 months, was referred for hyperpyrexia (>40°C) that persisted for 15 days. At admission, there was elevation of transaminases, anemia (hemoglobin 8.9 g/dL), thrombocytopenia (platelet 135,000/mm3), and hypofibrinogenemia (fibrinogen 1.26 g/L). C-reactive protein was 10.7 mg/dL, lactate dehydrogenase 1270 U/L and ferritin 2380 ng/ mL, with hepatosplenomegaly and linfoadenomegaly. Hemophagocytic lymphohistiocytosis induced by direct stimulation of macrophages by interferon (IFN) was suspected. IFN was withdrawn as only measure and onemonth later signs and symptoms disappeared, with complete normalization of laboratory examinations. |
| Databáze: | OpenAIRE |
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