| Autor: |
Carlos, Arias-Cabrales, Montserrat, Folgueiras, Anna, Faura, Jorge, Eguia, Eduardo, Padilla, Sara, Hurtado, Laura, Ribera, Daniel, Echeverria-Esnal, María José, Pérez-Sáez, Dolores, Redondo-Pachón, Carla, Burballa, Anna, Buxeda, Laura, Llinàs-Mallol, Higini, Cao, Francesc, Barbosa, Xavier, Rovira, Florencia, Cima, Julio, Pascual, Marta, Crespo |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Transplantation. 107:457-465 |
| ISSN: |
0041-1337 |
| DOI: |
10.1097/tp.0000000000004433 |
| Popis: |
The original SARS-CoV-2 vaccination regimen (2 doses) induces insufficient short-term response in kidney transplant (KT) recipients. This study assessed the response to a third dose and the long-term immunogenicity after 2 doses in KT.We analyzed the dynamics of the humoral and cellular response by monitoring SARS-CoV-2 IgG antibodies against the Spike-protein (IgG-Spike) and QuantiFERON SARS-CoV-2 IFN-γ release assay 6 mo after the second dose (T2) and 28 d after the third dose of mRNA vaccines (T3) to KT and controls (dialysis patients and healthy individuals).At T2, the percentage of IgG-Spike+ KT and dialysis patients decreased (KT 65.8%-52.6%, hemodialysis 92.6-81.5%, and peritoneal dialysis 100%-90%), whereas 100% of healthy controls remained positive. About the cellular response, the percentage of responders decreased in all groups, especially in KT (22.4%-9.2%, P = 0.081). At T3, 92% of KT, 94%-98% of dialysis patients, and 100% of healthy controls were IgG-Spike+. In terms of antibody titers, patients and controls showed a reduction between T2 and T3 and about 80% of dialysis patients and 100% of controls achieved high titers after the third dose (1479.5 Binding Antibody Units/mL), whereas this percentage was only 50% in KT. With respect to the cellular response, only KT displayed a significant rise after the third dose.The third dose of mRNA vaccine improves both humoral and cellular responses, but less effectively in KT compared with dialysis patients and healthy controls. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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