Predictive role of tdf values in late rectal recto-sigmoid complications in irradiation treatment of cervix cancer
| Autor: | S.M. Deore, P S Viswanathan, S.J. Supe, Shyamkishore Shrivastava, Ketayun A. Dinshaw |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Cancer Research Time Factors Radiobiology Brachytherapy India Uterine Cervical Neoplasms Colon Sigmoid Carcinoma Humans Medicine Radiology Nuclear Medicine and imaging Radiation Injuries Cervix Aged Retrospective Studies Radiation Radiotherapy Epithelioma business.industry Rectum Dose fractionation Cancer Radiotherapy Dosage Middle Aged Prognosis medicine.disease Regimen medicine.anatomical_structure Oncology Female business Complication Nuclear medicine |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 24:217-221 |
| ISSN: | 0360-3016 |
| Popis: | Radiation-induced late rectal and recto-sigmoid complications for different doses per fraction were analyzed retrospectively in 203 cases of Stage IIIB carcinoma of the uterine cervix. The patients were treated with a combination of external irradiation and a single intracavitary insertion during January 1979 to December 1983. The external irradiation was randomised to deliver by four different fractionation regimens having dose per fraction of 2 Gy, 3 Gy, 4 Gy and 5.4 Gy. The doses for various fractionations were matched with the daily regimen using the time-dose factors (TDF) model. A single intracavitary insertion delivered a dose of 22 to 24 Gy to point A using Fletcher-Suit applicator. All patients had a minimum follow-up of 30 months. Thirty nine cases of late radiation induced rectal and recto-sigmoid complications were observed. The complication rate of 8.2% for daily treatment regimen delivering 2 Gy per fraction was increased to 33.3% for once weekly treatment regimen delivering 5.4 Gy per fraction (p = 0.041). Despite similar Time-Dose Factors (TDF) values in four different treatment regimens, the complication rate increased significantly in the once weekly regimen. The analysis suggest that the Time-Dose Factors (TDF) values do not predict correctly the late normal tissue reactions for different dose fractionation schedules. |
| Databáze: | OpenAIRE |
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